Project P01

Dissecting cellular and molecular routes to pancreatic cancer phenotypes through genome-wide genetic screening in mice

Principal Investigator

Roland Rad
   Klinik und Poliklinik für Innere Medizin II
   Technische Universität München

Projektbeschreibung in beliebiger Länge und Gestaltung sowie mit Bildern möglich.
We propose to use transposon-technologies developed by us to perform genome-wide in vivo screens in different compartments of the mouse pancreas: acinar, ductal, endocrine and progenitor cells. This will (i) uncover molecular networks required for neoplastic transformation of each cell type; and (ii) unravel if and how the cell of origin and its mutational landscape affect molecular, histopathologic and clinical cancer phenotypes.  ...