Project P01
Dissecting cellular and molecular routes to pancreatic cancer phenotypes through genome-wide genetic screening in mice
Principal Investigator
Prof. 
Roland Rad
Klinik und Poliklinik für Innere Medizin II
Technische Universität München
Email: roland.rad@tum.de
Homepage
Projektbeschreibung in beliebiger Länge und Gestaltung sowie mit Bildern möglich.
We propose to use transposon-technologies developed by us to perform genome-wide in vivo screens in different compartments of the mouse pancreas: acinar, ductal, endocrine and progenitor cells. This will (i) uncover molecular networks required for neoplastic transformation of each cell type; and (ii) unravel if and how the cell of origin and its mutational landscape affect molecular, histopathologic and clinical cancer phenotypes. ...
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